Yeh Cory, Bowers Daniel, Hadlock Tessa A
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA.
Arch Facial Plast Surg. 2007 Sep-Oct;9(5):333-9. doi: 10.1001/archfaci.9.5.333.
To examine the effect of the immunosuppressive agent FK506 on the rate of functional recovery of the rat facial nerve after crush injury.
Forty rats underwent facial nerve crush injury and were randomly assigned to 4 experimental groups: isotonic sodium chloride solution control, FK binding protein 52 (FKBP-52) antibody control, FK506, and FK506 and FKBP-52 antibody. Rats underwent daily recovery testing from postoperative day 9 until postoperative day 21 by videotaping 3 validated variables in this model: blink reflex return, vibrissial fibrillation loss, and return of vibrissial sweeping symmetry.
FK506-treated animals demonstrated improved recovery in all 3 variables compared with control animals. The FK506 and FKBP-52 antibody group demonstrated improved recovery of only the return of the blink reflex.
FK506 accelerated functional recovery of facial nerve function after crush injury. Neuroregeneration was inhibited by FKBP-52 antibody in the rat midface but not the upper face. FK506 may be a viable adjuvant treatment for facial nerve neurapraxic injury.
研究免疫抑制剂FK506对大鼠面神经挤压伤后功能恢复速率的影响。
40只大鼠接受面神经挤压伤，随机分为4个实验组：等渗氯化钠溶液对照组、FK结合蛋白52（FKBP - 52）抗体对照组、FK506组以及FK506与FKBP - 52抗体组。从术后第9天至术后第21天，通过拍摄该模型中3个已验证变量的视频对大鼠进行每日恢复测试：瞬目反射恢复、触须颤动消失以及触须扫动对称性恢复。
与对照动物相比，FK506治疗的动物在所有3个变量中均表现出更好的恢复。FK506与FKBP - 52抗体组仅在瞬目反射恢复方面表现出更好的恢复。
FK506可加速面神经挤压伤后功能的恢复。在大鼠面中部，FKBP - 52抗体抑制神经再生，但在上面部则不然。FK506可能是面神经失用性损伤的一种可行辅助治疗方法。
