Lal Devyani, Hetzler Laura T, Sharma Nijee, Wurster Robert D, Marzo Sam J, Jones Kathryn J, Foecking Eileen M
Department of Otolaryngology-Head and Neck Surgery, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA.
Otolaryngol Head Neck Surg. 2008 Jul;139(1):68-73. doi: 10.1016/j.otohns.2008.04.030.
To study the effect of electrical stimulation on accelerating facial nerve functional recovery from a crush injury in the rat model.
Experimental.
The main trunk of the right facial nerve was crushed just distal to the stylomastoid foramen, causing right-sided facial paralysis in 17 Sprague-Dawley rats. An electrode apparatus was implanted in all rats. Nine rats underwent electrical stimulation and eight were sham stimulated until complete facial nerve recovery. Facial nerve function was assessed daily by grading eyeblink reflex, vibrissae orientation, and vibrissae movement.
An electrical stimulation model of the rat facial nerve following axotomy was established. The semi-eyeblink returned significantly earlier (3.71 + 0.97 vs 9.57 + 1.86 days post axotomy) in stimulated rats (P = 0.008). Stimulated rats also recovered all functions earlier, and showed less variability in recovery time.
Electrical stimulation initiates and accelerates facial nerve recovery in the rat model as it significantly reduces recovery time for the semi-eyeblink reflex, a marker of early recovery. It also hastens recovery of other functions.
在大鼠模型中研究电刺激对加速面神经挤压伤后功能恢复的作用。
实验性研究。
在17只Sprague-Dawley大鼠中，将右侧面神经主干在茎乳孔远端进行挤压，导致右侧面部瘫痪。所有大鼠均植入电极装置。9只大鼠接受电刺激，8只接受假刺激，直至面神经完全恢复。通过对眨眼反射、触须方向和触须运动进行评分，每天评估面神经功能。
建立了大鼠面神经切断后的电刺激模型。电刺激组大鼠的半眨眼恢复明显更早（切断后3.71±0.97天对9.57±1.86天）（P = 0.008）。电刺激组大鼠的所有功能恢复也更早，且恢复时间的变异性更小。
电刺激可启动并加速大鼠模型中的面神经恢复，因为它显著缩短了半眨眼反射的恢复时间，而半眨眼反射是早期恢复的一个标志。它还能加速其他功能的恢复。
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