鱼油补充剂对健康志愿者心血管和内皮的影响。
Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers.
作者信息
Shah Atman Prabodh, Ichiuji Anne Marie, Han Janet K, Traina Mahmoud, El-Bialy Adel, Meymandi Sheba Kamal, Wachsner Robin Yvonne
机构信息
David Geffen School of Medicine at UCLA, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
出版信息
J Cardiovasc Pharmacol Ther. 2007 Sep;12(3):213-9. doi: 10.1177/1074248407304749.
Consumption of fish oil (FO) is associated with reduced adverse cardiovascular events. In a randomized, blinded, placebo-controlled trial, 26 subjects (17 men and 9 women; mean age [+/- SD] 31 +/- 3.7 years) received 1 g FO capsule (n = 14) or placebo (1 g of corn oil, n = 12) for 14 days. At day 0 and day 14, heart rate (HR), blood pressure, endothelium-dependent brachial artery flow-mediated vasodilation (EDV), and endothelium-independent nitroglycerin-mediated vasodilation (EIDV) were assessed with ultrasound. FO supplementation resulted in a significant increase in EDV (20.4% +/- 13.2% vs 9.9% +/- 5.4%; P = .036) and EIDV (32.6% +/- 16.8% vs 18.0% +/- 14.9%; P = .043). Resting HR decreased by a mean of 5.9 +/- 9.4 bpm (FO) compared with placebo (mean increase of 0.73 +/- 4.8 bpm [P = .05]). FO supplementation in healthy subjects is associated with improved endothelial function and decreased resting HR.
食用鱼油（FO）与不良心血管事件减少有关。在一项随机、双盲、安慰剂对照试验中，26名受试者（17名男性和9名女性；平均年龄[±标准差]31±3.7岁）接受1克鱼油胶囊（n = 14）或安慰剂（1克玉米油，n = 12），为期14天。在第0天和第14天，用超声评估心率（HR）、血压、内皮依赖性肱动脉血流介导的血管舒张（EDV）和非内皮依赖性硝酸甘油介导的血管舒张（EIDV）。补充鱼油导致EDV显著增加（20.4%±13.2%对9.9%±5.4%；P = 0.036）和EIDV显著增加（32.6%±16.8%对18.0%±14.9%；P = 0.043）。与安慰剂相比（平均增加0.73±4.8次/分钟[P = 0.05]），服用鱼油后静息心率平均降低5.9±9.4次/分钟。健康受试者补充鱼油与内皮功能改善和静息心率降低有关。
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