抗菌化合物对曼氏巴通体包囊形成及人脑血管内皮细胞细胞致病性的影响。
Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity.
作者信息
Siddiqui Ruqaiyyah, Matin Abdul, Warhurst David, Stins Monique, Khan Naveed Ahmed
机构信息
School of Biological and Chemical Sciences, Birkbeck College, University of London, London WC1E 7HX, England, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2007 Dec;51(12):4471-3. doi: 10.1128/AAC.00373-07. Epub 2007 Sep 17.
Abstract
Cycloheximide, ketoconazole, or preexposure of organisms to cytochalasin D prevented Balamuthia mandrillaris-associated cytopathogenicity in human brain microvascular endothelial cells, which constitute the blood-brain barrier. In an assay for inhibition of cyst production, these three agents prevented the production of cysts, suggesting that the biosynthesis of proteins and ergosterol and the polymerization of actin are important in cytopathogenicity and encystment.
摘要
放线菌酮、酮康唑或使生物体预先接触细胞松弛素D可防止曼氏巴通体在构成血脑屏障的人脑微血管内皮细胞中引发细胞致病性。在一项抑制囊肿产生的试验中，这三种药物可防止囊肿的产生，这表明蛋白质和麦角固醇的生物合成以及肌动蛋白的聚合在细胞致病性和包囊形成过程中发挥着重要作用。
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