Nowell Craig S, Farley Alison M, Blackburn C Clare
Institute for Stem Cell Research, University of Edinburgh, UK.
Methods Mol Biol. 2007;380:125-62. doi: 10.1007/978-1-59745-395-0_8.
T-cell development occurs principally in the thymus. Here, immature progenitor cells are guided through the differentiation and selection steps required to generate a complex T-cell repertoire that is both self-tolerant and has propensity to bind self major histocompatibility complex. These processes depend on an array of functionally distinct epithelial cell types within the thymic stroma, which have a common developmental origin in the pharyngeal endoderm. Here, we describe the structural and phenotypic attributes of the thymic stroma, and review current cellular and molecular understanding of thymus organogenesis.
T细胞发育主要发生在胸腺中。在这里，未成熟的祖细胞要经历一系列分化和选择步骤，才能产生一个既具有自身耐受性又倾向于结合自身主要组织相容性复合体的复杂T细胞库。这些过程依赖于胸腺基质中一系列功能不同的上皮细胞类型，它们在咽内胚层有共同的发育起源。在这里，我们描述了胸腺基质的结构和表型特征，并综述了目前对胸腺器官发生的细胞和分子理解。
