Agua-Doce Ana, Graça Luis
Instituto de Medicina Molecular, Universidade de Lisboa, Portugal.
Methods Mol Biol. 2007;380:405-29. doi: 10.1007/978-1-59745-395-0_26.
Monoclonal antibodies (MAb) have been shown to be effective in inducing immune tolerance in transplantation and autoimmunity. Several different MAb have tolerogenic properties and their effect has been studied in a range of experimental animal models and, in some cases, in clinical trials. The tolerant state seems to be maintained by CD4+ regulatory T cells (Treg), induced in the periphery, capable of suppressing other T cells specific for the same antigens or antigens presented by the same antigen presenting cells. Furthermore, following the initial induction of Treg cells under MAb treatment, Treg cells themselves can maintain the tolerant state in a dominant way in the absence of the therapeutic MAb or other immunosuppressive agents, and are able to recruit other T cells into the regulatory pool--a process named infectious tolerance.
单克隆抗体（MAb）已被证明在诱导移植和自身免疫中的免疫耐受方面有效。几种不同的单克隆抗体具有致耐受性特性，并且它们的作用已在一系列实验动物模型中进行了研究，在某些情况下，也在临床试验中进行了研究。耐受状态似乎由在外周诱导产生的CD4 +调节性T细胞（Treg）维持，这些Treg能够抑制针对相同抗原或由相同抗原呈递细胞呈递的抗原的其他T细胞。此外，在单克隆抗体治疗下最初诱导出Treg细胞后，Treg细胞自身能够在没有治疗性单克隆抗体或其他免疫抑制剂的情况下以显性方式维持耐受状态，并且能够将其他T细胞招募到调节池中——这一过程称为传染性耐受。
