Rutella Sergio, Lemoli Roberto M
Laboratory of Immunology, Department of Hematology, Catholic University Medical School, Largo Agostino Gemelli, 8, 00168 Rome, Italy.
Immunol Lett. 2004 Jun 15;94(1-2):11-26. doi: 10.1016/j.imlet.2004.04.015.
The induction of antigen (Ag)-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune homeostasis. Recently, attention has been focused on induction of active suppression by regulatory T cells (Treg cells). Also, a role for dendritic cells (DCs) in the promotion of peripheral tolerance has been demonstrated by several studies and is the subject of intensive investigation. It is currently believed that the maturation/activation state of DCs might be a control point for the induction of peripheral tolerance through modifications of the activation state of T cells. Several lines of experimental evidence suggest that unique DC subsets or discrete functional states of the DCs might be devoted to the promotion of Treg cell differentiation. The present review summarizes the emerging literature on the developmental origin and function of human Treg cells and tolerogenic/regulatory DCs. Furthermore, clinical implications of these studies for cellular therapy of immune-mediated pathologies are discussed.
诱导抗原特异性耐受对于预防自身免疫和维持免疫稳态至关重要。最近，人们的注意力集中在调节性T细胞（Treg细胞）诱导的主动抑制上。此外，多项研究已证明树突状细胞（DCs）在促进外周耐受中的作用，这也是深入研究的主题。目前认为，DCs的成熟/激活状态可能是通过改变T细胞激活状态来诱导外周耐受的控制点。几条实验证据表明，独特的DC亚群或DCs的离散功能状态可能有助于Treg细胞的分化。本综述总结了关于人类Treg细胞以及致耐受性/调节性DCs的发育起源和功能的最新文献。此外，还讨论了这些研究对免疫介导疾病细胞治疗的临床意义。
