Sigal-Zafrani B, Bollet M A, Antoni G, Savignoni A, Vincent-Salomon A, Pierga J-Y, Salmon R, Sastre-Garau X, Fourquet A
Department of Pathology, Institut Curie, Paris, France.
Br J Cancer. 2007 Oct 22;97(8):1046-52. doi: 10.1038/sj.bjc.6603991. Epub 2007 Sep 18.
The characteristics of ipsilateral breast tumour recurrences (IBTRs) relative to those of their primary tumours (PTs) remain scarcely studied. Of 70 young (< or =40 years) premenopausal women with IBTRs, we studied a series of 63 with paired histological data. Median follow-up since IBTR was 10 years. Rates of histological types, grades or hormonal receptors were not significantly different in PTs and in IBTRs. The concordance between IBTRs and their PTs was good for histological types. IBTRs with conserved histological types tended to occur more locally, but not significantly sooner than others. These IBTRs had good concordance for hormone receptors. In discordant cases there were as many losses as appearances of the receptors. The concordance was weak for grades, with equivalent numbers of IBTRs graded lower as higher than their PTs. The 10-year overall survival rate was 70%. Neither the conservation of histological type, location, nor of the two combined were associated with deaths. Early (<2 years) IBTRs, tended to be associated with poorer survival (HR=2.24 (0.92-5.41); P=0.08). IBTRs did not display features of higher aggressiveness than PTs. Neither clinical nor histological definition of a true recurrence could be established other than the conservation of the histological type.
相对于原发肿瘤（PT），同侧乳腺肿瘤复发（IBTR）的特征鲜有研究。在70例患有IBTR的年轻（≤40岁）绝经前女性中，我们研究了一组63例具有配对组织学数据的患者。自IBTR以来的中位随访时间为10年。PT和IBTR在组织学类型、分级或激素受体方面的发生率无显著差异。IBTR与其PT在组织学类型方面的一致性良好。组织学类型保留的IBTR往往更倾向于局部发生，但并不比其他IBTR显著更早出现。这些IBTR在激素受体方面具有良好的一致性。在不一致的病例中，受体丢失和出现的数量相同。分级方面的一致性较弱，IBTR分级低于或高于其PT的数量相当。10年总生存率为70%。组织学类型、位置的保留，或两者的组合均与死亡无关。早期（<2年）IBTR往往与较差的生存率相关（HR=2.24（0.92-5.41）；P=0.08）。IBTR未表现出比PT更高侵袭性的特征。除了组织学类型的保留外，无法确定真正复发的临床或组织学定义。
