Araujo Carolina R, Simão Luciano M, Ybarra Mariana I, Faria Natasha V M G, Botelho Caroline M, Moreira Marcos A, Teixeira Antônio L, Lana-Peixoto Marco A
Centro de Investigação em Esclerose Múltipla de Minas Gerais, Departamento de Oftalmologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Rua Santa Catarina 1011/801, 30170-080 Belo Horizonte, MG, Brazil.
Arq Neuropsiquiatr. 2007 Sep;65(3A):615-8. doi: 10.1590/s0004-282x2007000400013.
The Guy's neurological disability scale (GNDS) has recently been introduced as a new measure of disability in multiple sclerosis. It is patient-oriented, multidimensional, and not biased towards any particular disability. The purpose of the present study was to validate the Brazilian version of the GNDS. The adaptation of the scale was based on the translation/back-translation methodology. Sixty-two patients with clinically definite multiple sclerosis (CDMS) according to Poser's criteria were recruited for this study. GNDS was administered individually to each subject. The EDSS and the ambulation index (AI) scores were assigned by a neurologist. The intraclass correlation coefficient and the Cronbach's alpha values of the Brazilian version of GNDS (0.94 and 0.83, respectively) were comparable to the original one (0.98 and 0.79, respectively). Furthermore, the factor analysis of the Brazilian version of GNDS suggested, as the original article, a four-factor solution which accounted for 68.8% of the total variance. The Brazilian version of GNDS was found to be clinically relevant as it correlated significantly with the EDSS and AI. In conclusion, the Brazilian version of GNDS can be considered an important tool to evaluate the disability in MS patients, with clinical usefulness and psychometrics soundness.
盖伊神经功能障碍量表（GNDS）最近被引入作为评估多发性硬化症患者功能障碍的一种新方法。它以患者为导向，具有多维度性，且不偏向于任何特定的功能障碍。本研究的目的是验证GNDS的巴西版本。该量表的改编基于翻译/回译方法。根据波泽标准，招募了62例临床确诊的多发性硬化症（CDMS）患者参与本研究。对每位受试者单独进行GNDS评估。由神经科医生给出扩展残疾状态量表（EDSS）和步行指数（AI）评分。GNDS巴西版本的组内相关系数和克朗巴哈系数值（分别为0.94和0.83）与原始版本（分别为0.98和0.79）相当。此外，GNDS巴西版本的因子分析与原文一样，显示出一个四因子解决方案，该方案解释了总方差的68.8%。发现GNDS巴西版本具有临床相关性，因为它与EDSS和AI显著相关。总之，GNDS巴西版本可被视为评估MS患者功能障碍的重要工具，具有临床实用性和心理测量学可靠性。
