Balthazar Marcio L F, Martinelli José E, Cendes Fernando, Damasceno Benito P
Department of Neurology, Medical School, State University of Campinas, 13083-970 Campinas, SP, Brazil.
Arq Neuropsiquiatr. 2007 Sep;65(3A):619-22. doi: 10.1590/s0004-282x2007000400014.
To study lexical semantic memory in patients with amnestic mild cognitive impairment (aMCI), mild Alzheimer's disease (AD) and normal controls.
Fifteen mild AD, 15 aMCI, and 15 normal control subjects were included. Diagnosis of AD was based on DSM-IV and NINCDS-ADRDA criteria, and that of aMCI, on the criteria of the International Working Group on Mild Cognitive Impairment, using CDR 0.5 for aMCI and CDR 1 for mild AD. All subjects underwent semantic memory tests (Boston Naming-BNT, CAMCOG Similarities item), Rey Auditory Verbal Learning Test (RAVLT), Mini-Mental Status Examination (MMSE), neuropsychological tests (counterproofs), and Cornell Scale for Depression in Dementia. Data analysis used Mann-Whitney test for intergroup comparisons and Pearson's coefficient for correlations between memory tests and counterproofs (statistical significance level was p<0.05).
aMCI patients were similar to controls on BNT and Similarities, but worse on MMSE and RAVLT. Mild AD patients scored significantly worse than aMCI and controls on all tests.
aMCI impairs episodic memory but tends to spare lexical semantic system, which can be affected in the early phase of AD.
研究遗忘型轻度认知障碍（aMCI）患者、轻度阿尔茨海默病（AD）患者及正常对照者的词汇语义记忆。
纳入15例轻度AD患者、15例aMCI患者和15例正常对照者。AD的诊断基于DSM-IV和NINCDS-ADRDA标准，aMCI的诊断基于轻度认知障碍国际工作组的标准，aMCI采用CDR 0.5，轻度AD采用CDR 1。所有受试者均接受语义记忆测试（波士顿命名测试-BNT、CAMCOG相似性项目）、雷伊听觉词语学习测验（RAVLT）、简易精神状态检查表（MMSE）、神经心理学测试（反证法）以及痴呆抑郁症状康奈尔量表测试。数据分析采用曼-惠特尼检验进行组间比较，采用皮尔逊系数分析记忆测试与反证法之间的相关性（统计学显著性水平为p<０.05）。
aMCI患者在BNT和相似性测试方面与对照组相似，但在MMSE和RAVLT测试中表现较差。轻度AD患者在所有测试中的得分均显著低于aMCI患者和对照组。
aMCI损害情景记忆，但词汇语义系统往往未受影响，而在AD早期阶段该系统可能会受到影响。
