膜联蛋白A5：从诊断领域迈向治疗领域
Annexin A5: shifting from a diagnostic towards a therapeutic realm.
作者信息
Kenis H, Hofstra L, Reutelingsperger C P M
机构信息
Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
出版信息
Cell Mol Life Sci. 2007 Nov;64(22):2859-62. doi: 10.1007/s00018-007-7297-2.
The surge in apoptosis research and the discovery of the phosphatidylserine binding properties of annexin A5 have propelled a tremendous interest in cell death detection technologies. In the past years, annexin A5 has evolved from an efficient assay for detection of apoptotic cells in vitro to an in vivo molecular imaging technology with potential clinical use. A second key discovery, the specific internalization properties of annexin A5, has opened the opportunity to use annexin A5 for therapeutic applications. Annexin A5-mediated internalization creates a novel therapeutic platform for targeted drug delivery and cell entry to treat various diseases, including cancer and cardiovascular disease.
细胞凋亡研究的激增以及膜联蛋白A5磷脂酰丝氨酸结合特性的发现，激发了人们对细胞死亡检测技术的极大兴趣。在过去几年中，膜联蛋白A5已从一种体外检测凋亡细胞的有效方法发展成为一种具有潜在临床应用价值的体内分子成像技术。第二个关键发现，即膜联蛋白A5的特异性内化特性，为其用于治疗应用开辟了机会。膜联蛋白A5介导的内化作用为靶向药物递送和细胞进入创造了一个新型治疗平台，用于治疗包括癌症和心血管疾病在内的各种疾病。
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