Kenis Heidi, Reutelingsperger Chris
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands.
Curr Pharm Des. 2009;15(23):2719-23. doi: 10.2174/138161209788923903.
Targeted delivery of cytotoxic agents limits the severe toxic side-effects of anti-cancer drugs on healthy tissues. Annexin A5 is a well explored probe to target phosphatidylserine (PS)-expressing cells in vivo. Our novel understanding of the cellular and molecular mechanism of annexin A5 as a cell-entry agent and the finding that PS is expressed on living tumour as well as endothelial cells in the tumour vasculature, will allow the development of lead compounds for anti-cancer therapy.
细胞毒性药物的靶向递送可限制抗癌药物对健康组织的严重毒副作用。膜联蛋白A5是一种在体内靶向磷脂酰丝氨酸（PS）表达细胞的研究充分的探针。我们对膜联蛋白A5作为细胞进入剂的细胞和分子机制的新认识，以及PS在活肿瘤细胞和肿瘤脉管系统中的内皮细胞上表达的发现，将有助于开发用于抗癌治疗的先导化合物。
