Center for Health, Intervention, and Prevention, University of Connecticut, 2006 Hillside Rd., Unit 1248, Storrs, CT, 06269-1248, USA.
AIDS Behav. 2009 Feb;13(1):66-75. doi: 10.1007/s10461-007-9311-y. Epub 2007 Sep 18.
High levels of adherence to antiretroviral therapy (ART) are critical to the management of HIV, yet many people living with HIV do not achieve these levels. There is a substantial body of literature regarding correlates of adherence to ART, and theory-based multivariate models of ART adherence are emerging. The current study assessed the determinants of adherence behavior postulated by the Information-Motivation-Behavioral Skills model of ART adherence in a sample of 149 HIV-positive patients in Mississippi. Structural equation modeling indicated that ART-related information correlated with personal and social motivation, and the two sub-areas of motivation were not intercorrelated. In this Deep South sample, being better informed, socially supported, and perceiving fewer negative consequences of adherence were independently related to stronger behavioral skills for taking medications, which in turn associated with self-reported adherence. The IMB model of ART adherence appeared to well characterize the complexities of adherence for this sample.
高水平的抗逆转录病毒疗法（ART）依从性对于 HIV 的管理至关重要，但许多 HIV 感染者并未达到这一水平。关于 ART 依从性的相关因素有大量文献，并且基于理论的 ART 依从性多变量模型正在出现。本研究评估了密西西比州 149 名 HIV 阳性患者样本中抗逆转录病毒治疗依从性信息-动机-行为技能模型中提出的依从行为决定因素。结构方程模型表明，ART 相关信息与个人和社会动机相关，而动机的两个亚领域不相互关联。在这个美国南部深处的样本中，信息更丰富、社会支持更多、感知到的依从性负面后果更少与更强的服药行为技能独立相关，而行为技能又与自我报告的依从性相关。ART 依从性的 IMB 模型似乎很好地描述了该样本的依从性复杂性。
