Fisher Jeffrey D, Fisher William A, Amico K Rivet, Harman Jennifer J
Department of Psychology and Center for Health/HIV Intervention and Prevention, University of Connecticut, Storrs, CT 06269-1020, USA.
Health Psychol. 2006 Jul;25(4):462-73. doi: 10.1037/0278-6133.25.4.462.
HIV-positive persons who do not maintain consistently high levels of adherence to often complex and toxic highly active antiretroviral therapy (HAART) regimens may experience therapeutic failure and deterioration of health status and may develop multidrug-resistant HIV that can be transmitted to uninfected others. The current analysis conceptualizes social and psychological determinants of adherence to HAART among HIV-positive individuals. The authors propose an information-motivation-behavioral skills (IMB) model of HAART adherence that assumes that adherence-related information, motivation, and behavioral skills are fundamental determinants of adherence to HAART. According to the model, adherence-related information and motivation work through adherence-related behavioral skills to affect adherence to HAART. Empirical support for the IMB model of adherence is presented, and its application in adherence-promotion intervention efforts is discussed.
未始终如一地严格坚持往往复杂且有毒性的高效抗逆转录病毒疗法（HAART）方案的HIV阳性者，可能会经历治疗失败和健康状况恶化，并且可能会产生耐多药HIV，这种病毒可传播给未受感染的其他人。当前的分析对HIV阳性个体坚持HAART的社会和心理决定因素进行了概念化。作者提出了一个HAART坚持的信息-动机-行为技能（IMB）模型，该模型假定与坚持相关的信息、动机和行为技能是坚持HAART的基本决定因素。根据该模型，与坚持相关的信息和动机通过与坚持相关的行为技能来影响对HAART的坚持。文中给出了对IMB坚持模型的实证支持，并讨论了其在促进坚持干预措施中的应用。
