Yellajoshyula Dhananjay, Patterson Ethan S, Kroll Kristen L
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Bioessays. 2007 Oct;29(10):949-52. doi: 10.1002/bies.20646.
In many animals, early development of the embryo is characterized by synchronous, biphasic cell divisions. These cell divisions are controlled by maternally inherited proteins and RNAs. A critical question in developmental biology is how the embryo transitions to a later pattern of asynchronous cell divisions and transfers the prior maternal control of development to the zygotic genome. The most-common model regarding how this transition from maternal to zygotic control is regulated posits that this is a consequence of the limitation of maternal gene products, due to their titration during early cell divisions. Here we discuss a recent article by Crest et al.1 that instead proposes that the balance of Cyclin-dependent Kinase 1 and Cyclin B (Cdk1-CycB) activity relative to that of the Drosophila checkpoint kinase Chk1 determines when asynchronous divisions begin.
在许多动物中，胚胎的早期发育以同步的双相细胞分裂为特征。这些细胞分裂由母系遗传的蛋白质和RNA控制。发育生物学中的一个关键问题是胚胎如何过渡到后期的异步细胞分裂模式，并将先前对发育的母系控制转移到合子基因组。关于这种从母系控制到合子控制的转变是如何调节的，最常见的模型认为，这是由于母系基因产物在早期细胞分裂过程中的滴定作用而受到限制的结果。在这里，我们讨论了Crest等人最近发表的一篇文章，该文章提出，细胞周期蛋白依赖性激酶1和细胞周期蛋白B（Cdk1-CycB）的活性与果蝇检查点激酶Chk1的活性之间的平衡决定了异步分裂何时开始。
