Anand Prachi, Murali K Y, Tandon Vibha, Chandra Ramesh, Murthy P S
Dr B R Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110 007, India.
Indian J Exp Biol. 2007 Aug;45(8):696-701.
In the streptozotocin induced diabetic rats treated separately with aqueous, ethanol, acetone and chloroform extracts of the seeds of B. nigra, the increase in serum glucose value between 0 and 1 hr of glucose tolerance test (GTT) was the least (29 mg/dl) in aqueous extract treated animals while it was 54, 44 and 44 mg/dl with chloroform, acetone and ethanol extracts respectively. In further studies carried out with aqueous extract, the effective dose was found to be 200 mg/kg body weight in GTT. Administration of 200 mg/kg body weight of aqueous extract to diabetic animals daily once for one month brought down fasting serum glucose (FSG) levels while in the untreated group FSG remained at a higher value. In the treated animals the increase in glycosylated hemoglobin (HbA1c) and serum lipids was much less when compared with the levels in untreated diabetic controls. These findings suggest that further studies with the aqueous extract of B. nigra seeds on its antidiabetic activity would be useful.
在分别用黑种草种子的水提取物、乙醇提取物、丙酮提取物和氯仿提取物处理的链脲佐菌素诱导的糖尿病大鼠中，葡萄糖耐量试验（GTT）0至1小时之间血清葡萄糖值的升高在水提取物处理的动物中最少（29毫克/分升），而氯仿、丙酮和乙醇提取物处理的动物分别为54、44和44毫克/分升。在用提取物进行的进一步研究中，发现在GTT中有效剂量为200毫克/千克体重。每天一次给糖尿病动物施用200毫克/千克体重的水提取物，持续一个月，可降低空腹血清葡萄糖（FSG）水平，而未治疗组的FSG仍保持在较高值。与未治疗的糖尿病对照组相比，治疗动物中糖化血红蛋白（HbA1c）和血脂的升高要少得多。这些发现表明，对黑种草种子水提取物的抗糖尿病活性进行进一步研究将是有用的。
