番木瓜对实验性诱导糖尿病大鼠的伤口愈合活性

Wound healing activity of Carica papaya L. in experimentally induced diabetic rats.

作者信息

Nayak Shivananda B, Pinto Pereira Lexley, Maharaj Dale

机构信息

Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad.

出版信息

Indian J Exp Biol. 2007 Aug;45(8):739-43.

PMID:17877152

Abstract

The aqueous extract of C. papaya fruit (100 mg kg(-1) day(-1) for 10 days) was evaluated for its wound healing activity in streptozotocin-induced diabetic rats using excision and dead space wound models. Extract-treated animals exhibited 77% reduction in the wound area when compared to controls which was 59%. The extract treated wounds were found to epithelize faster as compared to controls. The wet and dry granulation tissue weight and hydroxyproline content increased significantly when compared to controls. The extract exhibited antimicrobial activity against the five organisms tested. Carica papaya promotes significant wound healing in diabetic rats and further evaluation of this activity in humans is suggested.

摘要

番木瓜果实水提取物（100毫克/千克体重，连续给药10天），采用切除和死腔伤口模型，在链脲佐菌素诱导的糖尿病大鼠中评估其伤口愈合活性。与对照组相比，提取物处理组动物的伤口面积减少了77%，而对照组减少了59%。与对照组相比，提取物处理的伤口上皮化更快。与对照组相比，湿、干肉芽组织重量和羟脯氨酸含量显著增加。提取物对所测试的五种微生物均表现出抗菌活性。番木瓜能显著促进糖尿病大鼠的伤口愈合，建议进一步评估其在人体中的这种活性。