Porwal Sejal, Malviya Rishabha, Sundram Sonali, Sridhar Sathvik Belagodu, Shareef Javedh
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India.
Department of Pharmacy, RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah, United Arab Emirates.
Curr Drug Targets. 2025;26(6):367-381. doi: 10.2174/0113894501354898241220075327.
Managing diabetic wounds is a significant challenge for healthcare professionals since severe complications and delayed recovery greatly impact the patients' quality of life. This article aimed to explore various factors affecting diabetic wound healing, the mechanism of wound healing, and potential natural products having wound healing capability. It focuses on mechanisms of action and the therapeutic effectiveness of the compounds employed in the management of diabetic wounds. The review discusses the function of nutrition in wound healing, emphasizing the significance of consuming adequate amounts of protein, energy, lipids, amino acids, vitamins, minerals, and water to promote healing. Several herbs, including , and , are being tested for wound healing qualities in diabetes circumstances. These plants have a variety of modes of action, including antioxidant, anti-inflammatory, antibacterial, and immunomodulatory activities that help to speed up wound healing, stimulate collagen formation, and promote tissue regeneration. The variety of action mechanisms seen in natural products, especially in plants, offers hope for the treatment of diabetic wounds. It may also be possible to improve healing results and the quality of life of diabetes individuals with chronic wounds by including these herbal treatments in wound care programs.
对于医护人员而言，处理糖尿病伤口是一项重大挑战，因为严重的并发症和愈合延迟会极大地影响患者的生活质量。本文旨在探讨影响糖尿病伤口愈合的各种因素、伤口愈合的机制以及具有伤口愈合能力的潜在天然产物。它着重于用于处理糖尿病伤口的化合物的作用机制和治疗效果。该综述讨论了营养在伤口愈合中的作用，强调摄入足够量的蛋白质、能量、脂质、氨基酸、维生素、矿物质和水对促进愈合的重要性。几种草药，包括[此处列举的草药名称缺失]，正在糖尿病情况下进行伤口愈合特性的测试。这些植物具有多种作用方式，包括抗氧化、抗炎、抗菌和免疫调节活性，有助于加速伤口愈合、刺激胶原蛋白形成并促进组织再生。天然产物，尤其是植物中所呈现的多种作用机制，为糖尿病伤口的治疗带来了希望。通过将这些草药疗法纳入伤口护理方案，也有可能改善慢性伤口糖尿病患者的愈合效果和生活质量。
