Kraivaphan P, Amornchat C, Triratana T
Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 2007 May;38(3):594-7.
The objective of this study was to determine the effects of a triclosan/copolymer dentifrice on plaque formation, gingivitis and gingival bleeding in pregnant subjects. This double-blind clinical study was carried out in 180 women at 3 months of pregnancy. The subjects were stratified into two balanced groups according to their baseline plaque, gingivitis and bleeding scores. Subjects received a thorough dental prophylaxis and were assigned to brush with either a placebo or triclosan dentifrice for five months. They were instructed to brush their teeth as they normally would, twice a day for one minute per brushing. Follow-up examinations after five months of dentifrice use evaluated supragingival plaque, gingivitis and gingival bleeding. After five months, the triclosan dentifrice significantly reduced plaque formation, gingivitis and gingival bleeding by 40.5%, 22.5% and 35.3%, respectively, compared to the placebo group (p<0.05).
本研究的目的是确定含三氯生/共聚物的牙膏对孕妇牙菌斑形成、牙龈炎和牙龈出血的影响。这项双盲临床研究在180名怀孕3个月的女性中进行。根据受试者的基线牙菌斑、牙龈炎和出血评分，将她们分为两个均衡的组。受试者接受了全面的牙齿预防治疗，并被分配使用安慰剂或含三氯生的牙膏刷牙5个月。他们被指示按照平时的方式刷牙，每天两次，每次刷牙1分钟。在使用牙膏5个月后的随访检查中，评估了龈上牙菌斑、牙龈炎和牙龈出血情况。5个月后，与安慰剂组相比，含三氯生的牙膏使牙菌斑形成、牙龈炎和牙龈出血分别显著减少了40.5%、22.5%和35.3%（p<0.05）。
