通过[3+2]环加成反应，由异吲哚酮和杂醛与甲亚胺叶立德的贝利斯-希尔曼加合物合成新型功能化3-螺吡咯烷并吲哚和3-螺吡咯烷氧化吲哚。
Synthesis of novel functionalized 3-spiropyrrolizidine and 3-spiropyrrolidine oxindoles from Baylis-Hillman adducts of isatin and heteroaldehydes with azomethine ylides via [3+2]-cycloaddition.
作者信息
Shanmugam Ponnusamy, Viswambharan Baby, Madhavan Suchithra
机构信息
Chemical Sciences and Technology Division, National Institute for Interdisciplinary Science and Technology, Trivandrum-695 019, Kerala, India.
出版信息
Org Lett. 2007 Oct 11;9(21):4095-8. doi: 10.1021/ol701533d. Epub 2007 Sep 18.
PMID:17877359
Abstract
A novel regioselective synthesis of a number of functionalized 3-spiropyrrolizidine and 3-spiropyrrolidine oxindoles from Baylis-Hillman adducts of isatin and heteroaldehydes via [3+2] cycloaddition of azomethine ylides in excellent yields has been reported.
摘要
据报道，通过异吲哚酮和杂醛的Baylis-Hillman加合物经甲亚胺叶立德的[3+2]环加成反应，以优异的产率新颖且区域选择性地合成了多种功能化的3-螺吡咯里西啶和3-螺吡咯烷氧化吲哚。
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