研磨石化学：螺[吖啶-9,2'-吲哚]-1,3,8-三酮衍生物的设计、一锅合成及对 MCF-7 癌细胞系的潜在抗癌活性。

Department of Chemistry, Nehru Memorial College, Affiliated Bharathidasan University, Puthanamapatti, Tamilnadu 621007, India.

Department of Zoology, College of Sciences, King Saud University (KSU), P.O. Box 2455, Riyadh 11451, Saudi Arabia.

Molecules. 2020 Dec 11;25(24):5862. doi: 10.3390/molecules25245862.

In this study, the synthesis of one-pot 10-phenyl-3,4,6,7-tetrahydro-1-spiro [acridine-9,2'-indoline]-1,3,8-trione derivatives was achieved via a four-component cyclocondensation reaction, which was carried out in solvent-free conditions, and using p-toluenesulfonic acid (p-TSA) as a catalyst. The product was confirmed by FT-IR, H-NMR, C-NMR, mass spectra, and elemental analysis. Furthermore, the anticancer activity was screened for all compounds. Among these compounds, compound was more effective (GI 0.01 µm) against MCF-7 cancer cell lines than standard and other compounds. Therefore, the objective of this study was achieved with a few promising molecules having been demonstrated to be potential anticancer agents.

在这项研究中，通过无溶剂条件下的四组分环缩合反应，成功合成了 1-茚满-9,2'-吖啶-1,3,8-三酮衍生物，并使用对甲苯磺酸（p-TSA）作为催化剂。通过傅里叶变换红外光谱（FT-IR）、氢核磁共振（H-NMR）、碳核磁共振（C-NMR）、质谱（MS）和元素分析确认了产物的结构。此外，对所有化合物进行了抗癌活性筛选。在这些化合物中，化合物对 MCF-7 癌细胞系的抑制作用（GI 0.01 µm）优于标准品和其他化合物。因此，本研究的目标是通过证明一些有前途的分子具有潜在的抗癌作用来实现。