从β-羟甲基环丙烷甲酰胺出发，对γ-亚氨基内酯、二氢喹啉-2-酮和γ-内酰胺进行发散性合成。
A divergent synthesis of gamma-iminolactones, dihydroquinolin-2-ones, and gamma-lactames from beta-hydroxymethylcyclopropanylamides.
作者信息
Xiong Tao, Zhang Qian, Zhang Zhiguo, Liu Qun
机构信息
Department of Chemistry, Northeast Normal University, Changchun, 130024, People's Republic of China.
出版信息
J Org Chem. 2007 Oct 12;72(21):8005-9. doi: 10.1021/jo701495s. Epub 2007 Sep 18.
PMID:17877406
Abstract
Gamma-iminolactones 2, dihydroquinolin-2-ones 3, and gamma-lactames 4 have been synthesized starting from beta-hydroxymethylcyclopropanylamides 1, mediated by SnCl4/NaI/NEt3, BF3.OEt2, and TiCl4/NEt3. The corresponding products 2, 3, and 4 were produced, respectively, in high to excellent yields.
摘要
已从β-羟甲基环丙烷甲酰胺1开始，在四氯化锡/碘化钠/三乙胺、三氟化硼·乙醚和四氯化钛/三乙胺的介导下合成了γ-亚氨基内酯2、二氢喹啉-2-酮3和γ-内酰胺4。分别以高至优异的产率得到了相应产物2、3和4。
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