通过邻炔基苯胺与醛的催化复分解反应合成2,3-二氢喹啉-4(1H)-酮
Synthesis of 2,3-dihydroquinolin-4(1H)-ones through catalytic metathesis of o-alkynylanilines and aldehydes.
作者信息
Saito Akio, Kasai Jun, Odaira Yu, Fukaya Haruhiko, Hanzawa Yuji
机构信息
Laboratory of Organic Reaction Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
出版信息
J Org Chem. 2009 Aug 7;74(15):5644-7. doi: 10.1021/jo900857c.
PMID:19496542
Abstract
SbF5-MeOH catalytic system efficiently promotes the alkyne-carbonyl metathesis of o-alkynylaniline derivatives and aldehydes to afford 2,3-disubstituted dihydroquinolinones in moderate to high yields with high trans-selectivity.
摘要
SbF5-甲醇催化体系能有效促进邻炔基苯胺衍生物与醛的炔基-羰基复分解反应，以中等至高产率和高反式选择性得到2,3-二取代二氢喹啉酮。
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