Malik M, Camm A J
Department of Cardiological Sciences, St George's Hospital Medical School, London, UK.
Med Biol Eng Comput. 1991 Jul;29(4):425-32. doi: 10.1007/BF02441665.
A three-dimensional model of myocardial tissue has been developed which incorporates electrotonic interactions between neighbouring myocytes. The algorithms of the model are based on asynchronous planning of discrete events. Each cellular element is described in a logical way and traces a predefined action potential which is dynamically modified depending on the electrotonic interactions. The model has a low computational complexity and has been implemented on personal workstations even for experiments investigating arrhythmogenic processes and simulating several tens of cycles in blocks composed of several thousand elements. The paper describes the algorithmic implementation of the model and presents three series of experiments examining the dependence of the accuracy of the model on the size of the modelled tissue, changes of the shape of simulated T-waves due to electrotonic interactions and arrhythmogenic processes caused by lowering the threshold of the electric flow which excites individual cells.
已开发出一种心肌组织的三维模型，该模型纳入了相邻心肌细胞之间的电紧张相互作用。该模型的算法基于离散事件的异步规划。每个细胞元件都以逻辑方式进行描述，并追踪一个预定义的动作电位，该动作电位会根据电紧张相互作用动态修改。该模型具有较低的计算复杂度，甚至已在个人工作站上实现，用于研究致心律失常过程以及模拟由数千个元件组成的模块中的数十个周期的实验。本文描述了该模型的算法实现，并展示了三组实验，这些实验考察了模型准确性对建模组织大小的依赖性、由于电紧张相互作用导致的模拟T波形状变化以及因降低激发单个细胞的电流阈值而引发的致心律失常过程。
