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使用心肌离子电流模型重建心电图。

Reconstruction of electrocardiogram using ionic current models for heart muscles.

作者信息

Yamanaka A, Okazaki K, Urushibara S, Kawato M, Suzuki R

出版信息

Jpn Heart J. 1986 Nov;27 Suppl 1:185-93.

PMID:2434677
Abstract

A digital computer model is presented for the simulation of the electrocardiogram during ventricular activation and repolarization (QRS-T waves). The part of the ventricular septum and the left ventricular free wall of the heart are represented by a two dimensional array of 730 homogeneous functional units. Ionic currents models are used to determine the spatial distribution of the electrical activities of these units at each instant of time during simulated cardiac cycle. In order to reconstruct the electrocardiogram, the model is expanded three-dimensionally with equipotential assumption along the third axis and then the surface potentials are calculated using solid angle method. Our digital computer model can be used to improve the understanding of the relationship between body surface potentials and intracellular electrical events.

摘要

提出了一种数字计算机模型,用于模拟心室激活和复极化过程中的心电图(QRS-T波)。心脏的室间隔部分和左心室游离壁由730个均匀功能单元的二维阵列表示。离子电流模型用于确定模拟心动周期中每个时刻这些单元电活动的空间分布。为了重建心电图,该模型沿第三轴采用等电位假设进行三维扩展,然后使用立体角法计算表面电位。我们的数字计算机模型可用于增进对体表电位与细胞内电活动之间关系的理解。

相似文献

1
Reconstruction of electrocardiogram using ionic current models for heart muscles.使用心肌离子电流模型重建心电图。
Jpn Heart J. 1986 Nov;27 Suppl 1:185-93.
2
Simulation of T wave based on cardiac model of electrical activity: effects of anisotropy of myocardium and inhomogeneity of ventricular gradient on QRS-T angle.基于心脏电活动模型的T波模拟:心肌各向异性和心室梯度不均匀性对QRS-T夹角的影响
Jpn Heart J. 1986 Nov;27 Suppl 1:255-66.
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Simulation of the QRS complex using papillary muscle positions as the site of early activation in human subjects.利用乳头肌位置作为人体早期激活部位对QRS波群进行模拟。
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Quantitative prediction of body surface potentials from myocardial action potentials using a summed dipole model.使用总和偶极子模型从心肌动作电位对体表电位进行定量预测。
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Analysis of cardiac ventricular wall motion based on a three-dimensional electromechanical biventricular model.基于三维机电双心室模型的心室壁运动分析
Phys Med Biol. 2005 Apr 21;50(8):1901-17. doi: 10.1088/0031-9155/50/8/018. Epub 2005 Apr 6.
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Parameter estimation in cardiac ionic models.心脏离子模型中的参数估计
Prog Biophys Mol Biol. 2004 Jun-Jul;85(2-3):407-31. doi: 10.1016/j.pbiomolbio.2004.02.002.
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Reconstruction of transport currents during repolarization: biochemical basis.
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Simulation of late potentials and arrhythmias by use of a three-dimensional heart model: casuality of peri-infarctional slow conduction in ventricular fibrillation.使用三维心脏模型模拟晚期电位和心律失常:心室颤动时梗死周边缓慢传导的因果关系
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3-dimensional computer simulation of depolarization and repolarization processes in the myocardium.心肌去极化和复极化过程的三维计算机模拟。
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引用本文的文献

1
Computer simulation of electronic interactions during excitation and repolarisation of myocardial tissue.心肌组织兴奋和复极化过程中电子相互作用的计算机模拟。
Med Biol Eng Comput. 1991 Jul;29(4):425-32. doi: 10.1007/BF02441665.