Bromilow I M, Duguid J K
Mersey Regional Transfusion Centre, Liverpool, England, UK.
Med Lab Sci. 1991 Jul;48(3):212-6.
A blood group chimaera is described whose red blood cells exhibit a dual population of group A1 and O, in the proportions 20% and 80% respectively. These results could also indicate a blood group mosaic of the Amos type, but family studies, secretor and transferase investigations on this patient suggest that blood group chimaerism of unestablished type is more likely. There was no further evidence of chimaerism found during cytogenetic investigations, immunoglobulin allotyping or studies of red cell enzyme systems. Blood group chimaeras were previously thought to be rare, as dual red cell populations and the resulting mixed-field agglutination patterns are not always easy to recognise. This case is the second example of chimaerism found within two years in a single routine laboratory, appearing to confirm the view that chimaerism is not as uncommon as previously thought.
本文描述了一名血型嵌合体患者，其红细胞呈现出A1型和O型两种细胞群体，比例分别为20%和80%。这些结果也可能表明是阿莫斯（Amos）型血型镶嵌，但对该患者的家系研究、分泌型及转移酶检测表明，更可能是未明确类型的血型嵌合体。在细胞遗传学检查、免疫球蛋白同种异型分型或红细胞酶系统研究中，未发现进一步的嵌合证据。以前认为血型嵌合体很罕见，因为双红细胞群体及由此产生的混合视野凝集模式并不总是容易识别。该病例是在一个常规实验室两年内发现的第二例嵌合体病例，似乎证实了嵌合体并不像以前认为的那样罕见的观点。
