Choudhury Pratim K, Ranawat Mahendra S, Pillai Mousumi K, Chauhan Chetan S
Department of Pharmacy, Fiji School of Medicine, Suva, Fiji Islands.
Acta Pharm. 2007 Sep;57(3):343-50. doi: 10.2478/v10007-007-0027-3.
An asymmetric membrane capsule of cellulose acetate for osmotic delivery of flurbiprofen has been developed and influence of osmogents and solubilizing agent on in vitro drug release were evaluated. The capsule membrane was prepared by the phase inversion technique. To ensure the osmotic delivery of drug, two approaches were adopted: (i) the drug was encapsulated with osmogents like sodium chloride and mannitol to increase the osmotic pressure of the core, and (ii) the drug was encapsulated with sodium lauryl sulfate in the core of the formulation to increase the solubility and thus its osmotic pressure. Scanning electron microscopy of the membrane confirmed its porous, dense asymmetric nature. Dye test revealed in situ pore formation. The in vitro release study showed that as the proportion of osmogent and solubilizing agent was increased the release rate also increased. A good correlation was observed between the zero-order rate constant and the amount of the osmogent and solubilizing agent used.
已开发出一种用于氟比洛芬渗透给药的醋酸纤维素不对称膜胶囊，并评估了渗透剂和增溶剂对体外药物释放的影响。胶囊膜采用相转化技术制备。为确保药物的渗透给药，采用了两种方法：（i）将药物与氯化钠和甘露醇等渗透剂一起包封，以增加核心的渗透压；（ii）在制剂核心中用十二烷基硫酸钠包封药物，以增加溶解度从而提高其渗透压。膜的扫描电子显微镜检查证实了其多孔、致密的不对称性质。染料试验显示原位形成孔。体外释放研究表明，随着渗透剂和增溶剂比例的增加，释放速率也增加。在零级速率常数与所用渗透剂和增溶剂的量之间观察到良好的相关性。
