Choudhury Pratim K, Chauhan Chetan S, Ranawat Mahendra S
Department of Pharmacy, Fiji School of Medicine, Suva, Fiji Islands.
Drug Dev Ind Pharm. 2007 Oct;33(10):1135-41. doi: 10.1080/03639040701386087.
The release of poorly water-soluble drug, flurbiprofen, through asymmetric membrane capsule of cellulose acetate containing different pore forming agents like glycerol, polyethylene glycol 400, and dibutyl phthalate, in presence of sodium lauryl sulfate was investigated. The asymmetric membrane was fabricated in the shape of capsule body and cap by phase inversion technique. The type of pore forming agent incorporated had a marked influence on the porosity of the asymmetric membrane. However flurbiprofen due to its poor solubility was unable to create enough osmotic pressure and hence less than 10% of drug was released from all the systems with out SLS. However when the study was conducted with SLS, a maximum release of 72% was observed from the capsule with 70% glycerol. The release rates were found to increase with the increase in the concentration of pore forming agent and the amount of SLS encapsulated.
研究了在十二烷基硫酸钠存在的情况下，难溶性药物氟比洛芬通过含有不同致孔剂（如甘油、聚乙二醇400和邻苯二甲酸二丁酯）的醋酸纤维素不对称膜胶囊的释放情况。通过相转化技术将不对称膜制成胶囊体和帽的形状。所加入的致孔剂类型对不对称膜的孔隙率有显著影响。然而，由于氟比洛芬溶解度差，无法产生足够的渗透压，因此在没有十二烷基硫酸钠的情况下，所有体系中药物释放量均低于10%。然而，当在十二烷基硫酸钠存在下进行研究时，观察到含有70%甘油的胶囊中药物最大释放量为72%。发现释放速率随着致孔剂浓度和包封的十二烷基硫酸钠量的增加而增加。
