Ouyang Z, Gao L, Fico M, Chappell W J, Noll R J, Cooks R G
Department of Chemistry and Schools of Electrical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Eur J Mass Spectrom (Chichester). 2007;13(1):13-8. doi: 10.1255/ejms.832.
Quadrupole ion traps are reviewed, emphasizing recent developments, especially the investigation of new geometries, guided by multiple particle simulations such as the ITSIM program. These geometries include linear ion traps (LITs) and the simplified rectilinear ion trap (RIT). Various methods of fabrication are described, including the use of rapid prototyping apparatus (RPA), in which 3D objects are generated through point-by-point laser polymerization. Fabrication in silicon using multilayer semi-conductor fabrication techniques has been used to construct arrays of micro-traps. The performance of instruments containing individual traps as well as arrays of traps of various sizes and geometries is reviewed. Two types of array are differentiated. In the first type, trap arrays constitute fully multiplexed mass spectrometers in which multiple samples are examined using multiple sources, analyzers and detectors, to achieve high throughput analysis. In the second, an array of individual traps acts collectively as a composite trap to increase trapping capacity and performance for a single sample. Much progress has been made in building miniaturized mass spectrometers; a specific example is a 10 kg hand-held tandem mass spectrometer based on the RIT mass analyzer. The performance of this instrument in air and water analysis, using membrane sampling, is described.
本文对四极离子阱进行了综述，重点介绍了近期的发展情况，特别是在多粒子模拟（如ITSIM程序）的指导下对新几何结构的研究。这些几何结构包括线性离子阱（LIT）和简化的直线离子阱（RIT）。文中描述了各种制造方法，包括使用快速成型设备（RPA），通过逐点激光聚合生成三维物体。利用多层半导体制造技术在硅中进行制造已被用于构建微阱阵列。本文还综述了包含单个阱以及各种尺寸和几何结构的阱阵列的仪器的性能。区分了两种类型的阵列。在第一种类型中，阱阵列构成了完全多路复用的质谱仪，其中使用多个源、分析仪和探测器对多个样品进行检测，以实现高通量分析。在第二种类型中，单个阱的阵列共同充当复合阱，以提高单个样品的捕获能力和性能。在构建小型化质谱仪方面已经取得了很大进展；一个具体的例子是基于RIT质量分析仪的10千克手持式串联质谱仪。描述了该仪器在空气和水分析中使用膜采样的性能。
