Anabtawi Mona, Beck Preston, Lemons Jack
Department of Prosthodontics, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294-0007, USA.
J Biomed Mater Res B Appl Biomater. 2008 Feb;84(2):478-85. doi: 10.1002/jbm.b.30894.
Surface characterization was performed to evaluate the surface condition of an uncoated cobalt alloy disc (control), and discs with medium and thick boron coatings for total joint articulating surfaces. Discs were characterized by scanning electron microscopy before and after dissolution studies. Chemical analyses of elemental transfer to the solution were assessed to evaluate the surface stability of the new coating. An in vivo biocompatibility study for particulates [of boron (B), titanium alloy (Ti), cobalt alloy (Co), and combinations of B + Ti and B + Co] was performed using a rat air pouch model. The inflammatory reactions to particulates were evaluated histologically and histochemically. No physical alteration was seen in the discs after the dissolution studies, and the elemental transfer to the dissolution solution was minimal. The cytokines, tumor necrosis factor (TNFalpha), and histology results from these simulated debris showed similar and moderate level responses magnitudes for the boron and mixtures and the primary alloy particulates. The conclusion from this initial study was that assessments of the coated discs showed physical properties similar to control. Also results from the in vivo studies of simulated wear debris from boron coatings on titanium and cobalt alloys demonstrated biocompatibility profiles that were mild to moderate and similar to prior analyses of wear debris products in synovial pouch models.
进行表面表征以评估未涂层钴合金盘（对照）以及用于全关节关节表面的具有中等厚度和厚硼涂层的盘的表面状况。在溶解研究前后，通过扫描电子显微镜对盘进行表征。评估元素向溶液中的转移的化学分析，以评估新涂层的表面稳定性。使用大鼠气袋模型对[硼（B）、钛合金（Ti）、钴合金（Co）以及B + Ti和B + Co组合的]颗粒进行体内生物相容性研究。通过组织学和组织化学方法评估对颗粒的炎症反应。溶解研究后，在盘中未观察到物理变化，并且元素向溶解溶液中的转移极少。这些模拟碎片产生的细胞因子、肿瘤坏死因子（TNFα）和组织学结果显示，硼及其混合物与主要合金颗粒的反应程度相似且为中等水平。这项初步研究的结论是，对涂层盘的评估显示其物理性能与对照相似。此外，对钛合金和钴合金上硼涂层的模拟磨损碎片的体内研究结果表明，其生物相容性特征为轻度至中度，与滑膜袋模型中先前对磨损碎片产物的分析相似。
