Alzheimer research forum discussion: gain or loss of function - time to shake up assumptions on gamma-secretase in Alzheimer disease?
出版信息
J Alzheimers Dis. 2007 Jun;11(3):399-417. doi: 10.3233/jad-2007-11315.
PMID:17879480
Abstract
摘要
相似文献
1
Alzheimer research forum discussion: gain or loss of function - time to shake up assumptions on gamma-secretase in Alzheimer disease?阿尔茨海默病研究论坛讨论：功能获得还是功能丧失——是时候撼动关于阿尔茨海默病中γ-分泌酶的假设了？
J Alzheimers Dis. 2007 Jun;11(3):399-417. doi: 10.3233/jad-2007-11315.
2
Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease.阿尔茨海默病中功能丧失性早老素突变。关于早老素突变在阿尔茨海默病中作用的讨论要点。
EMBO Rep. 2007 Feb;8(2):141-6. doi: 10.1038/sj.embor.7400897.
3
Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.早老素蛋白和γ-分泌酶：结构、功能及其在阿尔茨海默病中的作用。
Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006304. doi: 10.1101/cshperspect.a006304.
4
Physiological functions of presenilins; beyond γ-secretase.早老素的生理功能；超越γ-分泌酶
Curr Pharm Biotechnol. 2014;15(11):1019-25. doi: 10.2174/1389201015666141122204139.
5
Presenilins and the gamma-secretase: still a complex problem.早老素和γ-分泌酶：仍然是一个复杂的问题。
Mol Brain. 2010 Feb 5;3:7. doi: 10.1186/1756-6606-3-7.
6
Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.早老素作为内质网钙泄漏通道与阿尔茨海默病发病机制。
Sci China Life Sci. 2011 Aug;54(8):744-51. doi: 10.1007/s11427-011-4201-y. Epub 2011 Jul 24.
7
Alzheimer's disease sends the wrong signals--a perspective.阿尔茨海默病发出错误信号——一种观点。
Amyloid. 2008 Mar;15(1):1-4. doi: 10.1080/13506120701814608.
8
Presenilins: members of the gamma-secretase quartets, but part-time soloists too.早老素：γ-分泌酶四聚体成员，但也有单独发挥作用的时候。
Physiology (Bethesda). 2008 Aug;23:194-204. doi: 10.1152/physiol.00009.2008.
9
Putting presenilins centre stage. Introduction to the Talking Point on the role of presenilin mutations in Alzheimer disease.将早老素推至核心地位。关于早老素突变在阿尔茨海默病中作用的讨论要点介绍。
EMBO Rep. 2007 Feb;8(2):134-5. doi: 10.1038/sj.embor.7400899.
10
Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase.早老素的跨膜结构域9决定了γ-分泌酶催化位点的动态构象。
J Biol Chem. 2008 Jul 11;283(28):19793-803. doi: 10.1074/jbc.M802461200. Epub 2008 May 15.
引用本文的文献
1
Hereditary and sporadic forms of abeta-cerebrovascular amyloidosis and relevant transgenic mouse models.遗传性和散发性的β-脑动脉淀粉样血管病以及相关的转基因小鼠模型。
Int J Mol Sci. 2009 Apr 23;10(4):1872-1895. doi: 10.3390/ijms10041872.
Zotero 插件