早老素和γ-分泌酶：仍然是一个复杂的问题。
Presenilins and the gamma-secretase: still a complex problem.
机构信息
Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia.
出版信息
Mol Brain. 2010 Feb 5;3:7. doi: 10.1186/1756-6606-3-7.
Abstract
The presenilins form part of a complex of membrane proteins that are involved in the proteolytic cleavage of cell-surface molecules. This article reviews the history of the discovery of the presenilins, their role in the pathogenesis of Alzheimer's disease and in the metabolism of the amyloid-beta precursor protein. Unanswered questions about their biochemical mechanism of action and their effects on Ca2+ homeostasis are examined.
摘要
早老素是参与细胞表面分子蛋白水解切割的膜蛋白复合物的一部分。本文回顾了早老素的发现历史、它们在阿尔茨海默病发病机制和淀粉样前体蛋白代谢中的作用。还研究了它们生化作用机制和对 Ca2+ 动态平衡影响方面的一些未解问题。
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