Rihmer Zoltán
National Institute for Psychiatry and Neurology, Budapest, Hungary.
Neuropsychopharmacol Hung. 2007 Mar;9(1):35-7.
A pooled analysis of randomized placebo controlled antidepressant trials shows that the rate of antidepressant and placebo responders are 50% and 30% respectively. The traditional calculation of drug-placebo difference (50-30=20%) in these drug-trials is based on the assumption that all placebo responders should be antidepressant responders. However, it seems to be not the case, since about one-third of placebo responders are antidepressant nonresponders. Considering this, the fair calculation of antidepressant-placebo difference in randomized placebo controlled trials results in a 30% rather than 20% difference. The drug-placebo differences in all antidepressant drug trials should be re-calculated.
一项对随机安慰剂对照抗抑郁药物试验的汇总分析表明，抗抑郁药物应答者和安慰剂应答者的比例分别为50%和30%。这些药物试验中传统的药物 - 安慰剂差异计算（50 - 30 = 20%）是基于所有安慰剂应答者都应是抗抑郁药物应答者这一假设。然而，情况似乎并非如此，因为约三分之一的安慰剂应答者是抗抑郁药物无应答者。考虑到这一点，在随机安慰剂对照试验中抗抑郁药物与安慰剂差异的合理计算结果是30%而非20%的差异。所有抗抑郁药物试验中的药物 - 安慰剂差异都应重新计算。
