Emery Charles F, Fondow Meghan D M, Schneider Carol M, Christofi Fievos L, Hunt Chantal, Busby Andrea K, Needleman Bradley J, Melvin W Scott, Elsayed-Awad Hamdy M
Department of Psychology, Ohio State University, Columbus, OH 43210, USA.
Obes Surg. 2007 Jun;17(6):759-63. doi: 10.1007/s11695-007-9140-0.
Prior studies have documented elevated symptoms of depression among patients undergoing gastric bypass surgery, in addition to significant elevations of inflammatory markers including C-reactive protein (CRP) and interleukin-6 (IL-6). No prior study has examined the relationship of changes in depression with change in inflammation among patients undergoing gastric bypass surgery. This pilot study was designed to examine the relationship of inflammation and depression among gastric bypass patients in a 12-month longitudinal study.
13 Caucasian women (mean age 46.9 +/- 5.7 years) who were scheduled to undergo a Roux-en-Y gastric bypass (RYGBP) were recruited prior to surgery for measurement of body mass and blood markers of inflammation, as well as self-report measures of depression, quality of life, and disordered eating. 12 months later, subjects completed the same battery of physiological and psychological measures. Data were analyzed with paired t-tests and Pearson correlations.
In addition to significant reductions in BMI (P < .001), participants experienced significant reductions in CRP (P < .001), IL-6 (P = .002), and depressive symptoms (P = .025). Reductions also were observed in binge eating (P = .005). Decreased depression during the 12-month follow-up was highly correlated with reduced CRP (r = .98, P < .001).
Results from this pilot study indicate that RYGBP is associated with significant reductions in inflammatory markers of cardiovascular disease risk (e.g., CRP, IL-6) and depressive symptoms, in addition to reductions in weight. Results suggested that reductions in depression were associated with the observed decreases in inflammation.
先前的研究记录了接受胃旁路手术的患者中抑郁症状增加，此外包括C反应蛋白（CRP）和白细胞介素-6（IL-6）在内的炎症标志物也显著升高。此前没有研究探讨过接受胃旁路手术的患者中抑郁变化与炎症变化之间的关系。这项初步研究旨在通过一项为期12个月的纵向研究来探讨胃旁路手术患者中炎症与抑郁之间的关系。
招募了13名计划接受Roux-en-Y胃旁路手术（RYGBP）的白人女性（平均年龄46.9±5.7岁），在手术前测量体重和炎症血液标志物，以及抑郁、生活质量和饮食失调的自我报告指标。12个月后，受试者完成相同的一系列生理和心理测量。数据采用配对t检验和Pearson相关性分析。
除了体重指数（BMI）显著降低（P<.001）外，参与者的CRP（P<.001）、IL-6（P=.002）和抑郁症状（P=.025）也显著降低。暴饮暴食情况也有所减少（P=.005）。在12个月的随访期间，抑郁症状的减轻与CRP的降低高度相关（r=.98，P<.001）。
这项初步研究的结果表明，RYGBP除了能减轻体重外，还与心血管疾病风险的炎症标志物（如CRP、IL-6）和抑郁症状的显著降低有关。结果表明，抑郁症状的减轻与观察到的炎症减轻有关。
