Winfield Robert D, Ang Darwin N, Chen Mike K, Kays David W, Langham Max R, Beierle Elizabeth A
University of Florida College of Medicine, Department of Surgery, Division of Pediatric Surgery, Gainesville, Florida, USA.
Am Surg. 2007 Aug;73(8):792-5.
Hyaluronate carboxymethylcellulose (Seprafilm; Genzyme Corp., Cambridge, MA) has been demonstrated to be safe and efficacious for the prevention of abdominal and pelvic adhesions; however, information is scarce regarding its use in children and adolescents. We wanted to characterize our experience with Seprafilm in a pediatric surgical population. After Institutional Review Board approval, we searched our hospital and pediatric surgery database for cases in which Seprafilm was used and retrospectively reviewed medical records for demographic and clinical information. Between July 2000 and October 2005, 18 patients had Seprafilm placed. Patients ranged in age from 0.25 to 18 years. Seven patients had not undergone any previous operations. Of patients having undergone prior surgery, the most common preceding intervention was a Ladd's procedure. Seprafilm was applied in a variety of scenarios, the most frequently being adhesiolysis for bowel obstruction. No patient required reoperation for obstruction. Two patients underwent subsequent operations for unrelated reasons; one was noted to have no significant adhesions, but the other had extensive adhesions. No patient demonstrated signs or symptoms of small bowel obstruction, intraperitoneal abscess, or localized inflammatory reaction to Seprafilm. Seprafilm was successfully used in our pediatric surgical population without complications.
透明质酸钠羧甲基纤维素（Seprafilm；健赞公司，马萨诸塞州剑桥）已被证明在预防腹部和盆腔粘连方面是安全有效的；然而，关于其在儿童和青少年中的使用信息却很少。我们想描述我们在儿科手术人群中使用Seprafilm的经验。经机构审查委员会批准后，我们在医院和儿科手术数据库中搜索使用Seprafilm的病例，并回顾性审查病历以获取人口统计学和临床信息。在2000年7月至2005年10月期间，有18例患者使用了Seprafilm。患者年龄在0.25岁至18岁之间。7例患者此前未接受过任何手术。在接受过先前手术的患者中，最常见的先前干预是Ladd手术。Seprafilm应用于多种情况，最常见的是用于肠梗阻的粘连松解术。没有患者因肠梗阻需要再次手术。2例患者因无关原因接受了后续手术；其中1例被发现没有明显粘连，但另一例有广泛粘连。没有患者出现小肠梗阻、腹腔脓肿或对Seprafilm的局部炎症反应的体征或症状。Seprafilm在我们的儿科手术人群中成功使用，无并发症发生。
