Magrupov B A, Alekseevskikh Iu G
Pediatriia. 1991(10):9-13.
The findings of 69 autopsies of children of the first year of life who died from pneumonia were examined. The children were found to have a significant lowering of IgA and IgG and an increase of IgM which correlated with the immunomorphological appearance of the organs of immunogenesis. The concentration of components C3 and C4 of complement was reduced. The reduction appeared most remarkable in +viral and bacterial pneumonias. The conclusion is drawn that in children of the first year of life, pneumonias eventuating in lethal outcomes may occur in primary and secondary immunodeficiency states, since the immune mechanisms are also implicated in the pathogenesis of pulmonary tissue lesions.
对69例死于肺炎的一岁儿童尸检结果进行了检查。发现这些儿童的IgA和IgG显著降低，IgM增加，这与免疫发生器官的免疫形态学表现相关。补体成分C3和C4的浓度降低。这种降低在病毒性和细菌性肺炎中最为明显。得出的结论是，在一岁儿童中，导致致命后果的肺炎可能发生在原发性和继发性免疫缺陷状态，因为免疫机制也参与了肺组织病变的发病过程。
