Giasuddin A S, Idoko J A, Lawande R V
Am J Trop Med Hyg. 1986 Nov;35(6):1231-4. doi: 10.4269/ajtmh.1986.35.1231.
Serum immunoglobulin (IgG, IgM, IgA) and complement (C3, C4) levels were measured by radial immunodiffusion technique in a group of 16 Nigerian patients with tropical pyomyositis (TP). Sixteen healthy Nigerians, age- and sex-matched with the patients, were also included in the study as control subjects (CS). A significantly low level of circulating IgM (P less than 0.01) and elevation of the serum levels of IgG (P less than 0.01) and IgA (P less than 0.01) were observed in TP compared to CS. Mean serum complement (C3, C4) levels were found to be similar in patients and controls. Microbiological culture tests showed that 14 pus specimens (88%) and 3 blood specimens (19%) from the patients were positive for Staphylococcus aureus. It was therefore proposed that IgM antibody deficiency (primary or acquired) against S. aureus may be the cause of tropical pyomyositis in Nigerians.
采用放射免疫扩散技术对16例尼日利亚热带脓性肌炎（TP）患者的血清免疫球蛋白（IgG、IgM、IgA）和补体（C3、C4）水平进行了检测。另外选取了16名年龄和性别与患者匹配的健康尼日利亚人作为对照（CS）纳入研究。与对照组相比，TP患者循环IgM水平显著降低（P<0.01），IgG（P<0.01）和IgA（P<0.01）血清水平升高。患者和对照组的平均血清补体（C3、C4）水平相似。微生物培养试验显示，患者的14份脓液标本（88%）和3份血液标本（19%）金黄色葡萄球菌检测呈阳性。因此，有人提出，尼日利亚人热带脓性肌炎的病因可能是针对金黄色葡萄球菌的IgM抗体缺乏（原发性或获得性）。
