通向可用于类似物合成的索德菌素核心的途径。
An avenue to the sordarin core adaptable to analog synthesis.
作者信息
Liang Huan, Schulé Arnaud, Vors Jean-Pierre, Ciufolini Marco A
机构信息
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.
出版信息
Org Lett. 2007 Oct 11;9(21):4119-22. doi: 10.1021/ol701547r. Epub 2007 Sep 20.
PMID:17880227
Abstract
We describe a synthesis of ketones 3 (X = O-R or CN; Y = H or alkyl), which are useful building blocks for the preparation of analogs of the potent antifungal agent sordarin, 1. Congeners of 1 constructed from 3 should permit detailed SAR investigations of the terpenoid core of the natural product.
摘要
我们描述了酮3（X = O-R或CN；Y = H或烷基）的合成，酮3是用于制备强效抗真菌剂索德菌素（1）类似物的有用构建单元。由3构建的1的同系物应能对该天然产物的萜类核心进行详细的构效关系研究。
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