对索拉菌素的合成研究：萜类核心及其类似物的构建模块。
Synthetic studies toward sordarin: building blocks for the terpenoid core and for analogues thereof.
作者信息
Schulé Arnaud, Liang Huan, Vors Jean-Pierre, Ciufolini Marco A
机构信息
Laboratoire de Synthèse et Méthodologie Organiques, CNRS UMR 5181, Université Claude Bernard Lyon 1 and Ecole Supérieure de Chimie, Physique, Electronique de Lyon, 43, Bd. du 11 Novembre 1918, 69622 Villeurbanne, France.
出版信息
J Org Chem. 2009 Feb 20;74(4):1587-97. doi: 10.1021/jo801911s.
Avenues to bi- and tricyclic building blocks for the elaboration of sordaricin and its analogues are described. The target molecules were obtained through inter- and intramolecular Diels-Alder reactions of a number of previously unknown cyclopentadienes. Unusual properties of 3-cyanoenones and 1-cyanocyclopentadienes have been unveiled and circumvented.
描述了用于合成索德菌素及其类似物的双环和三环结构单元的构建途径。目标分子是通过一些此前未知的环戊二烯的分子间和分子内狄尔斯-阿尔德反应获得的。已揭示并克服了3-氰基烯酮和1-氰基环戊二烯的异常性质。
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