Bull Joseph L
The University of Michigan, Department of Biomedical Engineering, 2142 Lurie Biomedical Engineering Building, 1107 Beal Avenue, Ann Arbor, MI 48109, USA.
Expert Opin Drug Deliv. 2007 Sep;4(5):475-93. doi: 10.1517/17425247.4.5.475.
Interest in microbubbles as vehicles for drug delivery has grown in recent years, due in part to characteristics that make them well suited for this role and in part to the need the for localized delivery of drugs in a number of applications. Microbubbles are inherently small, allowing transvascular passage, they can be functionalized for targeted adhesion, and can be acoustically driven, which facilitates ultrasound detection, production of bioeffects and controlled release of the cargo. This article provides an overview of related microbubble biofluid mechanics and reviews recent developments in the application of microbubbles for targeted drug delivery. Additionally, related advances in non-bubble microparticles for drug delivery are briefly described in the context of targeted adhesion.
近年来，人们对微泡作为药物递送载体的兴趣与日俱增，部分原因在于其特性使其非常适合这一角色，部分原因在于许多应用中对药物局部递送的需求。微泡本身尺寸小，能够通过血管，它们可以进行功能化修饰以实现靶向黏附，并且可以通过声学驱动，这有利于超声检测、产生生物效应以及控制所载物的释放。本文概述了相关的微泡生物流体力学，并综述了微泡在靶向药物递送应用方面的最新进展。此外，还在靶向黏附的背景下简要描述了用于药物递送的非泡微粒的相关进展。
