Jain Narendra K, Asthana Abhay
Dr Hari Singh Gour University, Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Sagar 4700 03, India.
Expert Opin Drug Deliv. 2007 Sep;4(5):495-512. doi: 10.1517/17425247.4.5.495.
The design of well-defined particulate carrier systems with controlled size, shapes and physicochemical characteristics is becoming a focal point in the field of biomedicine and drug delivery. Dendrimers are one of the emerging technologies of recent times and have served as a unique platform to achieve the development as novel drug delivery scaffolds. Dendrimers may be engineered to meet the specific needs of biologically active agents, which can either be encapsulated within dendrimers or chemically attached to these units. The large number of active functional groups on the surface of dendrimers allows them to be meticulously tailored and to act as nano-scaffolds or nano-containers of various categories of drugs. The architecture of modified dendrimers has posed a challenge to drug delivery, in particular with respect to their in vivo metabolic fate. The drug delivery applications of dendrimers presented in this article provide an insight of their potential and substantiate the major roles for the future of these nanoconstructs.
设计具有可控尺寸、形状和物理化学特性的明确颗粒载体系统正成为生物医学和药物递送领域的一个焦点。树枝状大分子是近年来新兴的技术之一，并且已成为实现作为新型药物递送支架发展的独特平台。可以对树枝状大分子进行工程设计以满足生物活性剂的特定需求，这些生物活性剂既可以封装在树枝状大分子内，也可以化学连接到这些单元上。树枝状大分子表面大量的活性官能团使其能够被精心定制，并充当各类药物的纳米支架或纳米容器。修饰后的树枝状大分子的结构对药物递送提出了挑战，特别是在其体内代谢命运方面。本文介绍的树枝状大分子的药物递送应用揭示了它们的潜力，并证实了这些纳米结构在未来的主要作用。
