Val-Bernal J Fernando, Val Daniel, Garijo M Francisca, Vega Alfonso, González-Vela M Carmen
Department of Anatomical Pathology, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria, Avenida Valdecilla s/n, E-39008 Santander, Spain.
J Cutan Pathol. 2007 Oct;34(10):788-92. doi: 10.1111/j.1600-0560.2006.00704.x.
Lipomas can undergo a variety of changes, one of which is ossification. Ossifying lipoma (OL), independent of bone tissue, is rare. No case has been reported with this heading in the dermatopathological literature.
A 73-year-old woman was referred for a subcutaneous mass on the left scapular region that had been present for more than 22 years.
The lesion was an OL measuring 8 cm and weighing 75 g. Only 25 cases of OL have been described in soft tissues. Including the present report, locations in order of frequency are the head and neck area (11 cases), the limbs (9 cases) and the trunk (6 cases). Average patient age is 50.9 years (range, 17-81 years). History is measured in years (mean, more than 6 years). Average tumor size is 7.1 cm (range, 0.8-20 cm). The adipose component is usually predominant and the mature bone tissue is irregular in distribution. Bone spicules are surrounded by fibrous tissue bands. Chondrous structures are found in 46.2% of tumors. No recurrences have been reported.
OL is rare but has a characteristic gross, radiological and histological appearance. It has the same prognosis as simple lipoma. Excision is the treatment to be chosen.
脂肪瘤可发生多种变化，其中之一是骨化。骨化性脂肪瘤（OL）独立于骨组织，较为罕见。在皮肤病理学文献中尚无以此为题的病例报道。
一名73岁女性因左肩胛区出现超过22年的皮下肿物前来就诊。
该病变为一个大小8 cm、重75 g的骨化性脂肪瘤。软组织中仅描述过25例骨化性脂肪瘤。包括本报告在内，按发生频率排序的部位依次为头颈部（11例）、四肢（9例）和躯干（6例）。患者平均年龄为50.9岁（范围17 - 81岁）。病程以年计（平均超过6年）。肿瘤平均大小为7.1 cm（范围0.8 - 20 cm）。脂肪成分通常占主导，成熟骨组织分布不规则。骨小梁被纤维组织带环绕。46.2%的肿瘤中发现软骨结构。尚无复发报道。
骨化性脂肪瘤罕见，但具有特征性的大体、影像学和组织学表现。其预后与单纯脂肪瘤相同。治疗应选择手术切除。
