脓毒症反应是好是坏？

Is the septic response good or bad?

机构信息

Academic Medical Center, Meibergdreef 9, Room G2-132, 1105 AZ Amsterdam, the Netherlands.

出版信息

Curr Infect Dis Rep. 2007 Sep;9(5):366-73. doi: 10.1007/s11908-007-0057-5.

DOI:10.1007/s11908-007-0057-5

Abstract

A careful balance between the inflammatory and anti-inflammatory response is vital in order to survive the daily invasion of pathogens. Sepsis has always been regarded as the result of an exacerbated detrimental inflammatory response towards invading bacteria. However, recent insights have forced us to rethink this sepsis paradigm. This review discusses the latest trends and developments in the sepsis field and helps to set the stage for the current debate on whether the sepsis response is good or bad.

摘要

在炎症反应和抗炎反应之间保持谨慎的平衡对于在日常病原体入侵中存活至关重要。败血症一直被认为是对入侵细菌的过度有害炎症反应的结果。然而，最近的研究进展迫使我们重新思考败血症的发病机制。本文讨论了败血症领域的最新趋势和进展，并为当前关于败血症反应是好是坏的争论奠定了基础。