Yeo Yoon, Kohane Daniel S
School of Pharmacy and Pharmaceutical Sciences, Weldon School of Biomedical Engineering, Purdue University, West Lafayelte IN, USA.
Eur J Pharm Biopharm. 2008 Jan;68(1):57-66. doi: 10.1016/j.ejpb.2007.03.027. Epub 2007 Jul 20.
Peritoneal adhesions are serious complications of surgery, and can result in pain, infertility, and potentially lethal bowel obstruction. Pharmacotherapy and barrier devices have reduced adhesion formation to varying degrees in preclinical studies or clinical trials; however, complete prevention of adhesions remains to be accomplished. We and others have hypothesized that the limitations of the two approaches could be overcome by combining their strengths in the context of controlled drug delivery. Here we review the role of polymeric systems in the prevention of peritoneal adhesions, with an emphasis on our recent work in developing and applying polymeric drug delivery systems such as nano- or microparticles, hydrogels, and hybrid systems for peritoneal use.
腹膜粘连是手术的严重并发症,可导致疼痛、不孕以及可能致命的肠梗阻。在临床前研究或临床试验中,药物治疗和屏障装置已在不同程度上减少了粘连的形成;然而,完全预防粘连仍有待实现。我们和其他人已经推测,在可控药物递送的背景下,将这两种方法的优势结合起来可以克服它们的局限性。在此,我们综述聚合物系统在预防腹膜粘连中的作用,重点介绍我们最近在开发和应用用于腹膜的聚合物药物递送系统方面的工作,如纳米或微粒、水凝胶和混合系统。