Department of gynecology and obstetrics, University Hospital of Nîmes, Nîmes, France.
Department of Artificial Polymers, Max Mousseron Institute of Biomolecules, CNRS UMR 5247, University of Montpellier 1, Montpellier, France.
PLoS One. 2018 Nov 5;13(11):e0202285. doi: 10.1371/journal.pone.0202285. eCollection 2018.
Peritoneal adhesions are a serious surgical postoperative complication. The aim of this study is to investigate, in a rat model, the anti-adhesive effects of a bioabsorbable film of polymer combining polyethylene glycol and polylactic acid.
Sixty-three animals were randomized into five groups according to the anti-adhesion treatment: Hyalobarrier®, Seprafilm®, Polymer A (PA), Polymer B (PB), and control. The rats were euthanized on days 5 and 12 to evaluate the extent, severity and degree of adhesions and histopathological changes. Three animals were euthanized at day 2 in PA, PB and control groups to observe the in vivo elimination.
Macroscopic adhesion formation was significantly lower in the PA group than in the control group at day 5 (median adhesion score 0±0 vs 9.6 ±0.5 p = 0.002) and at day 12 (0±0 vs 7.3±4 p = 0.02). Furthermore, median adhesion score at day 5 was significantly lower in the PA group than in the Seprafilm group (0±0 vs 4.2± 3.9 p = 0.03). Residence time of PA seems longer than PB.
The PA bioabsorbable film seems efficient in preventing the formation of peritoneal adhesions.
腹膜粘连是一种严重的术后并发症。本研究旨在通过大鼠模型，研究一种聚乙二醇和聚乳酸聚合物的可吸收膜对防止粘连的效果。
63 只动物随机分为五组，根据防粘连治疗分为：透明质酸钠凝胶膜（Hyalobarrier®）、聚维酮碘膜（Seprafilm®）、聚合物 A（PA）、聚合物 B（PB）和对照组。第 5 天和第 12 天处死大鼠，评估粘连的程度、严重程度和程度以及组织病理学变化。第 2 天处死 PA、PB 和对照组中的 3 只动物，观察体内消除情况。
第 5 天和第 12 天，PA 组的肉眼粘连形成明显低于对照组（中位数粘连评分 0±0 比 9.6±0.5，p=0.002；0±0 比 7.3±4，p=0.02）。第 5 天，PA 组的中位数粘连评分也明显低于 Seprafilm 组（0±0 比 4.2±3.9，p=0.03）。PA 的停留时间似乎比 PB 长。
PA 可吸收膜在预防腹膜粘连形成方面似乎有效。
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