从不吸烟者患肺癌——一种不同的疾病。

Lung cancer in never smokers--a different disease.

作者信息

Sun Sophie, Schiller Joan H, Gazdar Adi F

机构信息

Division of Haematology and Oncology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

出版信息

Nat Rev Cancer. 2007 Oct;7(10):778-90. doi: 10.1038/nrc2190.

DOI:10.1038/nrc2190

PMID:17882278

Abstract

Although most lung cancers are a result of smoking, approximately 25% of lung cancer cases worldwide are not attributable to tobacco use, accounting for over 300,000 deaths each year. Striking differences in the epidemiological, clinical and molecular characteristics of lung cancers arising in never smokers versus smokers have been identified, suggesting that they are separate entities. This Review summarizes our current knowledge of this unique and poorly understood disease.

摘要

虽然大多数肺癌是吸烟所致，但全球约25%的肺癌病例与烟草使用无关，每年导致超过30万例死亡。已确定从不吸烟者与吸烟者患肺癌在流行病学、临床和分子特征方面存在显著差异，这表明它们是不同的实体。本综述总结了我们目前对这种独特且了解不足的疾病的认识。