Biberman R, Lusky A, Schlesinger T, Margaloit M, Neeman E, Modan B
Department of Clinical Epidemiology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Arch Environ Health. 1993 Jul-Aug;48(4):209-12. doi: 10.1080/00039896.1993.9940361.
Alpha track radon detectors were placed in the homes of 35 lung cancer patients and 35 matched controls for a period of 8 to 10 mo. Twenty lung cancer patients had small cell lung carcinoma; 11 had adenocarcinoma, 2 had squamous cell carcinoma, and 2 had unclassified carcinoma among 15 nonsmokers. Mean overall living on ground level was significantly higher in the group with small cell lung carcinoma (50 y +/- 15) than among controls (33 y +/- 19); the adjusted odds ratio for lung cancer was 5.2 (90% confidence interval [90% CI] = 1.1-24.9) per decade of living on the ground floor for the group with small cell lung carcinoma. Radon exposure of more than 1.0 pci/l in the group with small cell lung carcinoma was associated with increased risk of lung cancer, although it did not reach statistical significance [odds ratio = 1.5 (90% CI = 0.4-5.4)], adjusting for differences in smoking habits. Our study supports the presence of a differentially increased risk for small cell lung carcinoma following long-term radon exposure.
在35名肺癌患者和35名匹配的对照者家中放置了α径迹氡探测器，为期8至10个月。20名肺癌患者患有小细胞肺癌；15名非吸烟者中，11名患有腺癌，2名患有鳞状细胞癌，2名患有未分类癌。小细胞肺癌组的平均地面居住总时长（50岁±15岁）显著高于对照组（33岁±19岁）；小细胞肺癌组每在底层居住十年，患肺癌的调整优势比为5.2（90%置信区间[90%CI]=1.1-24.9）。尽管在调整吸烟习惯差异后，小细胞肺癌组氡暴露超过1.0皮居里/升与肺癌风险增加相关，但未达到统计学显著性[优势比=1.5（90%CI=0.4-5.4）]。我们的研究支持长期氡暴露后小细胞肺癌存在差异增加的风险。
