以急性髓系白血病为表现的范可尼贫血：一例报告

Fanconi anemia presenting as acute myeloid leukemia: a case report.

作者信息

Bhatia Alka, Dash Sumitra, Varma Neelam, Marwaha R K

机构信息

Department of Haematology, Postgraduate Institute of Medical Education and Research, Chandigarh.

出版信息

Indian J Pathol Microbiol. 2007 Apr;50(2):441-3.

PMID:17883104

Abstract

Fanconi anemia is an autosomal recessive disorder characterized by phenotypic abnormalities, increased chromosomal breaks and predisposition to various hematological and non-hematological malignancies. We present case report of a paediatric patient with Fanconi anemia presenting as acute myeloid leukemia. The presence of dysplastic features in this marrow suggests the possibility of a prior stage of myelodysplasia progressing to leukemia.

摘要

范可尼贫血是一种常染色体隐性疾病，其特征为表型异常、染色体断裂增加以及易患各种血液系统和非血液系统恶性肿瘤。我们报告一例以急性髓系白血病为表现的范可尼贫血儿科患者。该骨髓中发育异常特征的存在提示骨髓发育异常前期进展为白血病的可能性。