Yusim K, Parnas H, Segel L
Department of Applied Mathematics and Computer Science, The Weizmann Institute of Science, Rehovot 76100, Israel.
Bull Math Biol. 1999 Jul;61(4):701-25. doi: 10.1006/bulm.1999.0107.
A molecular-level theory is constructed for the control of fast neurotransmitter release, based on recent experimental findings that depolarization shifts presynaptic autoreceptors to a low affinity state and that an autoreceptor must be bound to a transmitter before it can become associated with the exocytotic apparatus. It is assumed that such an association blocks release; experimental support for this assumption is cited. The theory provides mechanisms for key experimental results concerning the essence of the matter, what controls the time course of evoked release? The same general model can account for both evoked and spontaneous release. The new theory can be regarded as a molecular implementation of the (phenomenological) calcium-voltage hypothesis that was suggested earlier.
基于最近的实验发现构建了一个用于控制快速神经递质释放的分子水平理论，这些发现包括去极化将突触前自身受体转变为低亲和力状态，以及自身受体必须先与递质结合才能与胞吐装置相关联。假定这种关联会阻断释放；文中引用了对这一假定的实验支持。该理论为关于关键实验结果的本质提供了机制，即是什么控制了诱发释放的时间进程？同一个通用模型可以解释诱发释放和自发释放。新理论可被视为早期提出的（现象学的）钙电压假说的分子层面实现。
