Khanin Raya, Parnas Itzchak, Parnas Hanna
Department of Statistics, University of Glasgow, Glasgow, G12 8QW, UK.
Bull Math Biol. 2006 Jul;68(5):997-1009. doi: 10.1007/s11538-006-9099-3. Epub 2006 May 23.
This review describes the development of the molecular level Ca(2+)-voltage hypothesis. Theoretical considerations and feedback between theory and experiments played a key role in its development. The theory, backed by experiments, states that at fast synapses, membrane potential by means of presynaptic inhibitory autoreceptors controls initiation and termination of neurotransmitter release. A molecular kinetic scheme which depicts initiation and termination of evoked release is discussed. This scheme is able to account for both spontaneous release and evoked release. The physiological implications of this scheme are enumerated.
本综述描述了分子水平钙 - 电压假说的发展。理论思考以及理论与实验之间的反馈在其发展过程中发挥了关键作用。该理论在实验的支持下表明，在快速突触处，膜电位通过突触前抑制性自身受体控制神经递质释放的起始和终止。文中讨论了一个描述诱发释放起始和终止的分子动力学方案。该方案能够解释自发释放和诱发释放。文中列举了该方案的生理学意义。
